Factor IX gene haplotypes in Amerindians.: An article from: Human Biology
Book Details
PublisherWayne State University Press
ISBN / ASINB00097KLAI
ISBN-13978B00097KLA8
MarketplaceFrance 🇫🇷
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This digital document is an article from Human Biology, published by Wayne State University Press on February 1, 1997. The length of the article is 2317 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: We have determined the haplotypes of the factor IX gene for 95 Indians from 5 Brazilian Amazon tribes: Wayampi, Wayana-Apalai, Kayapo, Arara, and Yanomami. Eight polymorphisms linked to the factor IX gene were investigated: MseI (at 5[prime], nt - 698), BamHI (at 5[prime], nt -561), DdeI (intron 1), BamHI (intron 2), XmnI (intron 3), TaqI (intron 4), MspI (intron 4), and HhaI (at 3[prime], [approximately]8 kb). The results of the haplotype distribution and the allele frequencies for each of the factor IX gene polymorphisms in Amerindians were similar to the results reported for Asian populations but differed from results for other ethnic groups. Only five haplotypes were identified within the entire Amerindian study population, and the haplotype distribution was significantly different among the five tribes, with one (Arara) to four (Wayampi) haplotypes being found per tribe. These findings indicate a significant heterogeneity among the Indian tribes and contrast with the homogeneous distribution of the [Beta]-globin gene cluster haplotypes but agree with our recent findings on the distribution of [Alpha]-globin gene cluster haplotypes and the allele frequencies for six VNTRs in the same Amerindian tribes. Our data represent the first study of factor IX-associated polymorphisms in Amerindian populations and emphasizes the applicability of these genetic markers for population and human evolution studies.
Citation Details
Title: Factor IX gene haplotypes in Amerindians.
Author: Rendrik R. Franco
Publication:Human Biology (Refereed)
Date: February 1, 1997
Publisher: Wayne State University Press
Volume: v69 Issue: n1 Page: p1(9)
Distributed by Thomson Gale
From the author: We have determined the haplotypes of the factor IX gene for 95 Indians from 5 Brazilian Amazon tribes: Wayampi, Wayana-Apalai, Kayapo, Arara, and Yanomami. Eight polymorphisms linked to the factor IX gene were investigated: MseI (at 5[prime], nt - 698), BamHI (at 5[prime], nt -561), DdeI (intron 1), BamHI (intron 2), XmnI (intron 3), TaqI (intron 4), MspI (intron 4), and HhaI (at 3[prime], [approximately]8 kb). The results of the haplotype distribution and the allele frequencies for each of the factor IX gene polymorphisms in Amerindians were similar to the results reported for Asian populations but differed from results for other ethnic groups. Only five haplotypes were identified within the entire Amerindian study population, and the haplotype distribution was significantly different among the five tribes, with one (Arara) to four (Wayampi) haplotypes being found per tribe. These findings indicate a significant heterogeneity among the Indian tribes and contrast with the homogeneous distribution of the [Beta]-globin gene cluster haplotypes but agree with our recent findings on the distribution of [Alpha]-globin gene cluster haplotypes and the allele frequencies for six VNTRs in the same Amerindian tribes. Our data represent the first study of factor IX-associated polymorphisms in Amerindian populations and emphasizes the applicability of these genetic markers for population and human evolution studies.
Citation Details
Title: Factor IX gene haplotypes in Amerindians.
Author: Rendrik R. Franco
Publication:Human Biology (Refereed)
Date: February 1, 1997
Publisher: Wayne State University Press
Volume: v69 Issue: n1 Page: p1(9)
Distributed by Thomson Gale
