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Micro-simulated moving bed (@mSMB) systems: A numerical study [An article from: Chemical Engineering Journal]
Book Details
Author(s)H.J. Subramani, A.S. Kurup
PublisherElsevier
ISBN / ASINB000P6NXZ8
ISBN-13978B000P6NXZ6
AvailabilityAvailable for download now
Sales Rank99,999,999
MarketplaceUnited States 🇺🇸
Description
This digital document is a journal article from Chemical Engineering Journal, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Continuous chromatographic separation processes like simulated moving bed (SMB) systems have been employed in petrochemicals, sugar, and more recently, in pharmaceutical industries by virtue of their superior separation efficiency. Miniaturization of chromatography-based analytical techniques (e.g., high performance liquid chromatography, micro-HPLC or @mHPLC) has already been successfully demonstrated in the last few years owing to the rapid development in MEMS technology. With such a rapid progress in technology, it is definitely possible to realize the miniaturization of a powerful continuous chromatographic process such as SMB. Micro-SMB (@mSMB) systems could not only inherit the merits of @mHPLC, but also provide efficient separation of compounds such as isomers and enantiomers that are otherwise very difficult to isolate. In this paper, new simulations of the performance of a @mSMB system for the separation of a mixture of phenol and o-cresol, using a robust numerical algorithm developed that mimics the dynamic operation of the @mSMB system, are presented. A systematic parametric sensitivity analysis that addresses the effects of various process parameters on the performance of the @mSMB system is also presented. High purities and yields of both phenol and o-cresol is achieved in the @mSMB by judicious choice of process parameters.
Description:
Continuous chromatographic separation processes like simulated moving bed (SMB) systems have been employed in petrochemicals, sugar, and more recently, in pharmaceutical industries by virtue of their superior separation efficiency. Miniaturization of chromatography-based analytical techniques (e.g., high performance liquid chromatography, micro-HPLC or @mHPLC) has already been successfully demonstrated in the last few years owing to the rapid development in MEMS technology. With such a rapid progress in technology, it is definitely possible to realize the miniaturization of a powerful continuous chromatographic process such as SMB. Micro-SMB (@mSMB) systems could not only inherit the merits of @mHPLC, but also provide efficient separation of compounds such as isomers and enantiomers that are otherwise very difficult to isolate. In this paper, new simulations of the performance of a @mSMB system for the separation of a mixture of phenol and o-cresol, using a robust numerical algorithm developed that mimics the dynamic operation of the @mSMB system, are presented. A systematic parametric sensitivity analysis that addresses the effects of various process parameters on the performance of the @mSMB system is also presented. High purities and yields of both phenol and o-cresol is achieved in the @mSMB by judicious choice of process parameters.
