Methylmercury genotoxicity: A novel effect in human cell lines of the central nervous system [An article from: Environment International]

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Description:
Methylmercury is an important source of environmental contamination and the central nervous system (CNS) is one of the main target organs. Methylmercury genotoxicity was already demonstrated in peripherical tissues but was never detected in the brain. Thus, the objective of this work was to verify its genotoxic effect using brain cell lines. Glioblastoma (U373) and neuroblastoma (B103) human cell lines were exposed to methylmercury (0-10 @mM). By measuring cellular viability, concentrations inducing