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Effects of prepulse intensity, duration, and bandwidth on perceived intensity of startling acoustic stimuli [An article from: Biological Psychology]
Description
This digital document is a journal article from Biological Psychology, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Intense abrupt stimuli can elicit a startle reflex; a weak 'prepulse' 30-300ms earlier can reduce both startle and perceived stimulus intensity. Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to understand brain disorders characterized by gating deficits. Compared to startle, PPI of perceived stimulus intensity (PPIPSI) may provide information that is distinct, and easier to acquire and analyze. To develop this experimental measure, we examined PPIPSI under different stimulus conditions. Both PPI and PPIPSI exhibited a non-linear relationship to prepulse intensity, with prepulses 15dB(A) above background causing maximal inhibition of both measures. A 50ms broadband noise prepulse produced maximal PPI and PPIPSI, whereas 5 and 20ms pure tone prepulses produced maximal PPIPSI and PPI, respectively. PPIPSI is a robust, parametrically sensitive and 'low tech' measure of sensory gating that may become a valuable tool for understanding the biology of certain mental disorders.
Description:
Intense abrupt stimuli can elicit a startle reflex; a weak 'prepulse' 30-300ms earlier can reduce both startle and perceived stimulus intensity. Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to understand brain disorders characterized by gating deficits. Compared to startle, PPI of perceived stimulus intensity (PPIPSI) may provide information that is distinct, and easier to acquire and analyze. To develop this experimental measure, we examined PPIPSI under different stimulus conditions. Both PPI and PPIPSI exhibited a non-linear relationship to prepulse intensity, with prepulses 15dB(A) above background causing maximal inhibition of both measures. A 50ms broadband noise prepulse produced maximal PPI and PPIPSI, whereas 5 and 20ms pure tone prepulses produced maximal PPIPSI and PPI, respectively. PPIPSI is a robust, parametrically sensitive and 'low tech' measure of sensory gating that may become a valuable tool for understanding the biology of certain mental disorders.
