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Structural development of a minimally invasive sensor chip for blood glucose monitoring [An article from: Analytica Chimica Acta]
Book Details
PublisherElsevier
ISBN / ASINB000PDT8IC
ISBN-13978B000PDT8I4
MarketplaceUnited Kingdom 🇬🇧
Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Our newly developed glucose sensor chip has the world smallest blood sample volume, as small as 200nL, which makes lancing with less pain possible. Forming the inside walls of the cavity, where the blood is collected, by screen printing of the adhesive ink instead of the conventional adhesive sheet placing drastically reduced the cavity thickness, to less than 50@mm, and the blood sample volume. On this thin-cavity type sensor, the cavity thickness was proven to have the strong influence on the sensor response. This means that thinner cavity requires more accurate printing, in terms of thickness control. The printing conditions were adjusted to minimize the dispersion in the cavity geometry. One of the challenges was how to print patterns without saddles, which was achieved by selecting proper ink. After the adjustment, the contribution of the dispersion in the cavity thickness and the electrode area to the dispersion in sensor responses was estimated, respectively, which indicated the contribution of the cavity thickness still existed. Finally, the sensor was evaluated using whole sheep blood containing glucose of from 60 to 493mgdL^-^1. Irrespective of the influence relating to the cavity thickness, the coefficients of variation of the sensor responses were from 4.4 to 7.6. In addition, the correlation curve showed linearity in this blood glucose range, and the coefficient of determination r^2 was 0.98. That is, the sensor was verified to have sufficient performance for practical use.
Description:
Our newly developed glucose sensor chip has the world smallest blood sample volume, as small as 200nL, which makes lancing with less pain possible. Forming the inside walls of the cavity, where the blood is collected, by screen printing of the adhesive ink instead of the conventional adhesive sheet placing drastically reduced the cavity thickness, to less than 50@mm, and the blood sample volume. On this thin-cavity type sensor, the cavity thickness was proven to have the strong influence on the sensor response. This means that thinner cavity requires more accurate printing, in terms of thickness control. The printing conditions were adjusted to minimize the dispersion in the cavity geometry. One of the challenges was how to print patterns without saddles, which was achieved by selecting proper ink. After the adjustment, the contribution of the dispersion in the cavity thickness and the electrode area to the dispersion in sensor responses was estimated, respectively, which indicated the contribution of the cavity thickness still existed. Finally, the sensor was evaluated using whole sheep blood containing glucose of from 60 to 493mgdL^-^1. Irrespective of the influence relating to the cavity thickness, the coefficients of variation of the sensor responses were from 4.4 to 7.6. In addition, the correlation curve showed linearity in this blood glucose range, and the coefficient of determination r^2 was 0.98. That is, the sensor was verified to have sufficient performance for practical use.
