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TCDD alters PKC signaling pathways in developing neuronal cells in culture [An article from: Chemosphere]
Description
This digital document is a journal article from Chemosphere, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to induce neurodevelopmental deficits such as poor cognitive development and motor dysfunction. However, the mechanism of TCDD-mediated neurotoxicity remains unclear. Since PKC signaling is one of the most pivotal events involved in neuronal function and development, we analyzed the effects of TCDD on the PKC signaling pathway in cerebellar granule cells derived from PND-7 rat brain. Immunoblot analysis revealed the presence of PKC-@a, @bII, @d, @e, @l and @i in both cytosol and membrane fractions of cerebellar granule cells, but PKC-@c was below the detectable level. TCDD induced a significant translocation of PKC-@a, -@bII and -@e from cytosol to membrane fraction (p
Description:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to induce neurodevelopmental deficits such as poor cognitive development and motor dysfunction. However, the mechanism of TCDD-mediated neurotoxicity remains unclear. Since PKC signaling is one of the most pivotal events involved in neuronal function and development, we analyzed the effects of TCDD on the PKC signaling pathway in cerebellar granule cells derived from PND-7 rat brain. Immunoblot analysis revealed the presence of PKC-@a, @bII, @d, @e, @l and @i in both cytosol and membrane fractions of cerebellar granule cells, but PKC-@c was below the detectable level. TCDD induced a significant translocation of PKC-@a, -@bII and -@e from cytosol to membrane fraction (p
