An electrochemical approach for detecting copper-chelating properties of flavonoids using disposable pencil graphite electrodes: Possible implications ... [An article from: Analytica Chimica Acta]

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Description:
We have studied the electrochemistry of eight flavonoids belonging to four flavonoid sub-classes: flavone, flavonol, flavanol and anthocyanidin using pencil graphite electrodes (PGEs). We present the electrochemistry of delphinidin, cyanidin and catechin gallate for the first time. The use of electrochemical methods in connection with PGE in the study of flavonoids and their interaction with copper ions has not been previously reported. Our results compare favorably with previously reported studies, which utilised glassy carbon electrodes (GCEs) for the detection of flavonoids. We calibrated all eight flavonoids (r^2>0.9620), six of them at at least two peak potentials. The relative standard deviation (R.S.D.) for peak potential was delphinidin=baicalein>cyanidin>catechin. These findings may be significant in neuroscience and metal toxicological studies, in which copper ions have been reported to play a crucial role in initiating and/or promoting the progression of diseases such as Alzheimer's and Parkinson's.