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Metallothionein induction, antioxidative responses, glycogen and growth changes in Tubifex tubifex (Oligochaete) exposed to the fungicide, fenhexamid [An article from: Environmental Pollution]
Book Details
PublisherElsevier
ISBN / ASINB000RR3V6Q
ISBN-13978B000RR3V65
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Description
This digital document is a journal article from Environmental Pollution, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Laboratory studies were conducted to determine the effects of different concentrations of fenhexamid (0.1, 1, and 10 mg L^-^1) on growth, oxidative stress, protein, glycogen, and metallothionein (MT) contents in Tubifex tubifex after an exposure of 2, 4, and 7 days. In addition, residues of the fungicide were followed in water and in the worms. In water, fenhexamid concentration decreased slowly (maximum - 2+/-0.03% after 2 days for 1 mg L^-^1). In the worms, it increased after 4 days and decreased thereafter, confirming that the worms were exposed to the fungicide and not to a degradation product. LC"5"0 values were between 95.22+/-5.36 and 32.11+/-1.8 mg L^-^1 depending on exposure time. Exposure to fenhexamid had a negative effect on T. tubifex growth (maximum effect -12.2+/-0.8% after 7 days with 10 mg L^-^1) demonstrating the toxic effect of the pesticide. This growth rate decrease was accompanied by a reduction in protein and glycogen contents. The activity of catalase (CAT), and glutathione reductase (GR) increased in response to the fungicide demonstrating an oxidative stress in the worms. In contrast glutathion-S-transferase activity (GST) decreased. Exposure to fenhexamid also induced synthesis of MT (maximum +78+/-8% after 2 days for 10 mg L^-^1). The specificity of MT concentration increase in response to metals is discussed.
Description:
Laboratory studies were conducted to determine the effects of different concentrations of fenhexamid (0.1, 1, and 10 mg L^-^1) on growth, oxidative stress, protein, glycogen, and metallothionein (MT) contents in Tubifex tubifex after an exposure of 2, 4, and 7 days. In addition, residues of the fungicide were followed in water and in the worms. In water, fenhexamid concentration decreased slowly (maximum - 2+/-0.03% after 2 days for 1 mg L^-^1). In the worms, it increased after 4 days and decreased thereafter, confirming that the worms were exposed to the fungicide and not to a degradation product. LC"5"0 values were between 95.22+/-5.36 and 32.11+/-1.8 mg L^-^1 depending on exposure time. Exposure to fenhexamid had a negative effect on T. tubifex growth (maximum effect -12.2+/-0.8% after 7 days with 10 mg L^-^1) demonstrating the toxic effect of the pesticide. This growth rate decrease was accompanied by a reduction in protein and glycogen contents. The activity of catalase (CAT), and glutathione reductase (GR) increased in response to the fungicide demonstrating an oxidative stress in the worms. In contrast glutathion-S-transferase activity (GST) decreased. Exposure to fenhexamid also induced synthesis of MT (maximum +78+/-8% after 2 days for 10 mg L^-^1). The specificity of MT concentration increase in response to metals is discussed.
