![Diazepam and propofol used as anesthetics during open-heart surgery do not cause chromosomal aberrations in peripheral blood lymphocytes [An article ... Toxicology and Environmental Mutagenesis]](https://www.ebooknetworking.net/books/B00/0RR/bigB000RR4MBE.jpg)
Diazepam and propofol used as anesthetics during open-heart surgery do not cause chromosomal aberrations in peripheral blood lymphocytes [An article ... Toxicology and Environmental Mutagenesis]
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This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Diazepam is a benzodiazepine with anticonvulsant, anxiolytic, sedative and muscle-relaxing properties. Many aspects of its toxicity have been investigated, including genotoxic and carcinogenic effects in various model systems. However, it is still unclear whether diazepam is in fact a genotoxic agent. Propofol is a rapid-onset, short-acting intravenous anesthetic agent. It is used widely for the induction and maintenance of anesthesia as well as for long-term sedation in intensive care units. There is limited information in the literature on its genotoxic effects. Both drugs are commonly used as anesthetic in patients undergoing open-heart surgery. Therefore, we investigated the possible genotoxic effects of propofol and diazepam in those patients, using a chromosomal aberration (CA) assay. Peripheral blood samples were collected from 45 patients before induction of anesthesia and at the end of the anesthesia with diazepam or propofol. In Group I (n=24), anesthesia was induced with 0.2mgkg^-^1 diazepam and 10@mgkg^-^1 fentanyl. In Group II (n=21), anesthesia was induced with 1mgkg^-^1 propofol and 10@mgkg^-^1 fentanyl. Pancuronium bromide (0.1mgkg^-^1) was administered for skeletal muscle relaxation in both groups. Anesthesia was maintained by diazepam administration at 5mgkg^-^1 in Group I or by continuous propofol administration at 2-4mg(kgh)^-^1 in Group II. All patients received 0.02mgkg^-^1 pancuronium and 5@mgkg^-^1 fentanyl boluses at 30-40min intervals for anesthesia maintenance. Body temperature was controlled during bypass in the two groups. We found that the mean frequency of CAs in both groups before and at the end of the anesthesia were not statistically significantly different. Our analysis also indicated that age, smoking habit and gender were not confounding factors. In conclusion, our results indicate that diazepam and propofol do not exert genotoxic effects in blood cells during open-heart surgery.
Description:
Diazepam is a benzodiazepine with anticonvulsant, anxiolytic, sedative and muscle-relaxing properties. Many aspects of its toxicity have been investigated, including genotoxic and carcinogenic effects in various model systems. However, it is still unclear whether diazepam is in fact a genotoxic agent. Propofol is a rapid-onset, short-acting intravenous anesthetic agent. It is used widely for the induction and maintenance of anesthesia as well as for long-term sedation in intensive care units. There is limited information in the literature on its genotoxic effects. Both drugs are commonly used as anesthetic in patients undergoing open-heart surgery. Therefore, we investigated the possible genotoxic effects of propofol and diazepam in those patients, using a chromosomal aberration (CA) assay. Peripheral blood samples were collected from 45 patients before induction of anesthesia and at the end of the anesthesia with diazepam or propofol. In Group I (n=24), anesthesia was induced with 0.2mgkg^-^1 diazepam and 10@mgkg^-^1 fentanyl. In Group II (n=21), anesthesia was induced with 1mgkg^-^1 propofol and 10@mgkg^-^1 fentanyl. Pancuronium bromide (0.1mgkg^-^1) was administered for skeletal muscle relaxation in both groups. Anesthesia was maintained by diazepam administration at 5mgkg^-^1 in Group I or by continuous propofol administration at 2-4mg(kgh)^-^1 in Group II. All patients received 0.02mgkg^-^1 pancuronium and 5@mgkg^-^1 fentanyl boluses at 30-40min intervals for anesthesia maintenance. Body temperature was controlled during bypass in the two groups. We found that the mean frequency of CAs in both groups before and at the end of the anesthesia were not statistically significantly different. Our analysis also indicated that age, smoking habit and gender were not confounding factors. In conclusion, our results indicate that diazepam and propofol do not exert genotoxic effects in blood cells during open-heart surgery.
