![Induction of micronuclei in mouse bone-marrow erythrocytes in association with hypothermia after administration of the sigma receptor ligand E-5842 ... Toxicology and Environmental Mutagenesis]](https://www.ebooknetworking.net/books/B00/0RR/bigB000RR4MFA.jpg)
Induction of micronuclei in mouse bone-marrow erythrocytes in association with hypothermia after administration of the sigma receptor ligand E-5842 ... Toxicology and Environmental Mutagenesis]
Description
This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Oral administration of E-5842, a new @s"1 receptor ligand being developed as an antipsychotic drug, to male mice at single doses of 50, 100, 200 and 400mg/kg produced marked and sustained decreases in rectal temperature. Both the intensity and the duration of the hypothermic effect increased with dose. Maximum decreases from the mean pre-administration temperature (36.2^oC) ranged from 7.5 to 12.9^oC for animals receiving 50 and 400mg/kg doses, respectively. Examination of bone-marrow smears obtained 24, 48 and 72h after administration revealed a slight but statistically significant (p
Description:
Oral administration of E-5842, a new @s"1 receptor ligand being developed as an antipsychotic drug, to male mice at single doses of 50, 100, 200 and 400mg/kg produced marked and sustained decreases in rectal temperature. Both the intensity and the duration of the hypothermic effect increased with dose. Maximum decreases from the mean pre-administration temperature (36.2^oC) ranged from 7.5 to 12.9^oC for animals receiving 50 and 400mg/kg doses, respectively. Examination of bone-marrow smears obtained 24, 48 and 72h after administration revealed a slight but statistically significant (p
