![The thermodynamic dissociation constants of haemanthamine, lisuride, metergoline and nicergoline by the regression analysis of spectrophotometric data [An article from: Analytica Chimica Acta]](https://www.ebooknetworking.net/books/B00/0RR/bigB000RR6WLM.jpg)
The thermodynamic dissociation constants of haemanthamine, lisuride, metergoline and nicergoline by the regression analysis of spectrophotometric data [An article from: Analytica Chimica Acta]
Book Details
Author(s)M. Meloun, T. Syrovy, A. Vrana
PublisherElsevier
ISBN / ASINB000RR6WLM
ISBN-13978B000RR6WL4
MarketplaceFrance 🇫🇷
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This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
The mixed dissociation constants of four drugs - haemanthamine, lisuride, metergoline and nicergoline - at various ionic strengths I of range 0.01 and 0.6 and at temperatures of 25^oC and 37^oC were determined using SPECFIT32 and SQUAD(84) regression analyses of the pH-spectrophotometric titration data. A proposed strategy for efficient experimentation in a dissociation constants determination, followed by a computational strategy for the chemical model with a dissociation constants determination, is presented on the protonation equilibria of haemanthamine. Indices of precise methods predict the correct number of components, and even the presence of minor ones when the data quality is high and the instrumental error is known. The thermodynamic dissociation constant pK"a^T was estimated by non-linear regression of {pK"a, I} data at 25^oC and 37^oC: for haemanthamine pK"a^T=7.22(1) and 7.05 (2), for lisuride pK"a^T=7.87(1) and 7.59 (1), for metergoline pK"a^T=7.62(1) and 7.38 (1), for nicergoline pK"a","1^T=7.94(1) and 7.69 (1). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.
Description:
The mixed dissociation constants of four drugs - haemanthamine, lisuride, metergoline and nicergoline - at various ionic strengths I of range 0.01 and 0.6 and at temperatures of 25^oC and 37^oC were determined using SPECFIT32 and SQUAD(84) regression analyses of the pH-spectrophotometric titration data. A proposed strategy for efficient experimentation in a dissociation constants determination, followed by a computational strategy for the chemical model with a dissociation constants determination, is presented on the protonation equilibria of haemanthamine. Indices of precise methods predict the correct number of components, and even the presence of minor ones when the data quality is high and the instrumental error is known. The thermodynamic dissociation constant pK"a^T was estimated by non-linear regression of {pK"a, I} data at 25^oC and 37^oC: for haemanthamine pK"a^T=7.22(1) and 7.05 (2), for lisuride pK"a^T=7.87(1) and 7.59 (1), for metergoline pK"a^T=7.62(1) and 7.38 (1), for nicergoline pK"a","1^T=7.94(1) and 7.69 (1). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.
