![In vivo cytogenetic effects of a commercially formulated mixture of cypermethrin and quinalphos in mice [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis]](https://www.ebooknetworking.net/books/B00/0RR/bigB000RR824M.jpg)
In vivo cytogenetic effects of a commercially formulated mixture of cypermethrin and quinalphos in mice [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis]
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In vivo cytogenetic effects of commercially formulated cypermethrin (CYP, synthetic pyrethroid insecticide) and/or quinalphos (QUI, organophosphate insecticide), generally used in combination, were examined through chromosomal aberrations (CA) and micronucleus test (MT) in mice. Male mice were orally gavaged to a single dose of CYP/QUI commercial mixture (22, 44 or 67mg/kg b.wt.) for 24h (CA) or 48h (MT). Based on the concentrations of active ingredients of CYP and QUI present in the test doses of CYP/QUI mixture, mice were orally exposed to 0.66, 1.32 and 2mg/kg of CYP or 4.4, 8.8 and 13.4mg/kg of QUI. For reference, a group of five mice was intraperitoneally administered to cyclophosphamide (20 or 50mg/kg) or orally gavaged to peanut oil for vehicle control. Exposure of CYP/QUI mixture inhibited the mitotic index (MI) and induced CA in a dose-dependent manner at 24h; however, significant (p
Description:
In vivo cytogenetic effects of commercially formulated cypermethrin (CYP, synthetic pyrethroid insecticide) and/or quinalphos (QUI, organophosphate insecticide), generally used in combination, were examined through chromosomal aberrations (CA) and micronucleus test (MT) in mice. Male mice were orally gavaged to a single dose of CYP/QUI commercial mixture (22, 44 or 67mg/kg b.wt.) for 24h (CA) or 48h (MT). Based on the concentrations of active ingredients of CYP and QUI present in the test doses of CYP/QUI mixture, mice were orally exposed to 0.66, 1.32 and 2mg/kg of CYP or 4.4, 8.8 and 13.4mg/kg of QUI. For reference, a group of five mice was intraperitoneally administered to cyclophosphamide (20 or 50mg/kg) or orally gavaged to peanut oil for vehicle control. Exposure of CYP/QUI mixture inhibited the mitotic index (MI) and induced CA in a dose-dependent manner at 24h; however, significant (p
