Photopatterning and degradation study of dextran-glycidyl methacrylate hydrogels.(Report): An article from: Polymer Engineering and Science
Book Details
Author(s)Chi-Wei Lo, Hongrui Jiang
PublisherSociety of Plastics Engineers, Inc.
ISBN / ASINB00398HSHS
ISBN-13978B00398HSH4
AvailabilityAvailable for download now
MarketplaceUnited States 🇺🇸
Description
This digital document is an article from Polymer Engineering and Science, published by Society of Plastics Engineers, Inc. on February 1, 2010. The length of the article is 4429 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.
From the author: An approach to synthesizing photopatternable enzymatic degradable dextran hydrogel is presented. The glycidyl methacrylate derivatized dextran (Dex-GMA) was first prepared by reacting dextran with glycidyl methacrylate at 45[degrees]C with grafting efficiency of 10%. The degree of substitution (DS) was confirmed by [.sup.1]H-NMR. Next, Dex-GMA hydrogels were prepared by crosslinking in the presence of a crosslinker: N,N-methylene-bisacrylamide (NMBA), and a photoinitiator: 2,2'-dimethoxy-2-phenyl acetophenone (DMPA) in dimethyl sulfoxide (DMSO) solution. Further, the Dex-GMA hydrogels were photo patterned using liquid-phase photopolymerization ([LP.sup.3]) technique. The structure size ranged from 5 mm to 300 [micro]m and three different shapes of structures--round, square, and star--were demonstrated. The patterned Dex-GMA hydrogel structures not only exhibited mechanical robustness but also biodegradability. The dextranase-catalyzed degradation of Dex-GMA hydrogels with different DS was investigated at 37[degrees]C. The morphology of the degraded Dex-GMA hydrogels determined by SEM revealed the degree of enzymatic degradation due to dextranase. The Dex-GMA hydrogel was fully degraded by dextranase with concentration of 2 U/ml in 5 days. The Dex-GMA hydrogel also showed the ability to be readily integrated with microfluidics. POLYM. ENG. SCI., 50:232-239, 2010.
Citation Details
Title: Photopatterning and degradation study of dextran-glycidyl methacrylate hydrogels.(Report)
Author: Chi-Wei Lo
Publication:Polymer Engineering and Science (Magazine/Journal)
Date: February 1, 2010
Publisher: Society of Plastics Engineers, Inc.
Volume: 50 Issue: 2 Page: 232(8)
Article Type: Report
Distributed by Gale, a part of Cengage Learning
From the author: An approach to synthesizing photopatternable enzymatic degradable dextran hydrogel is presented. The glycidyl methacrylate derivatized dextran (Dex-GMA) was first prepared by reacting dextran with glycidyl methacrylate at 45[degrees]C with grafting efficiency of 10%. The degree of substitution (DS) was confirmed by [.sup.1]H-NMR. Next, Dex-GMA hydrogels were prepared by crosslinking in the presence of a crosslinker: N,N-methylene-bisacrylamide (NMBA), and a photoinitiator: 2,2'-dimethoxy-2-phenyl acetophenone (DMPA) in dimethyl sulfoxide (DMSO) solution. Further, the Dex-GMA hydrogels were photo patterned using liquid-phase photopolymerization ([LP.sup.3]) technique. The structure size ranged from 5 mm to 300 [micro]m and three different shapes of structures--round, square, and star--were demonstrated. The patterned Dex-GMA hydrogel structures not only exhibited mechanical robustness but also biodegradability. The dextranase-catalyzed degradation of Dex-GMA hydrogels with different DS was investigated at 37[degrees]C. The morphology of the degraded Dex-GMA hydrogels determined by SEM revealed the degree of enzymatic degradation due to dextranase. The Dex-GMA hydrogel was fully degraded by dextranase with concentration of 2 U/ml in 5 days. The Dex-GMA hydrogel also showed the ability to be readily integrated with microfluidics. POLYM. ENG. SCI., 50:232-239, 2010.
Citation Details
Title: Photopatterning and degradation study of dextran-glycidyl methacrylate hydrogels.(Report)
Author: Chi-Wei Lo
Publication:Polymer Engineering and Science (Magazine/Journal)
Date: February 1, 2010
Publisher: Society of Plastics Engineers, Inc.
Volume: 50 Issue: 2 Page: 232(8)
Article Type: Report
Distributed by Gale, a part of Cengage Learning
