NO news is good news - Detection, Measurement and Quantification of Nitric Oxide: Tools for Nitric Oxide Research (Euroscicon Meeting Reports)
Book Details
Author(s)Nicholas Warrick, Shara Cohen
PublisherHonnao
ISBN / ASINB008AL42KA
ISBN-13978B008AL42K0
MarketplaceCanada 🇨🇦
Description
Proceedings from the 23rd March 2007 meeting in Hertfordshire, UK
"Nitric oxide (NO), generated by the enzyme nitric oxide synthase (NOS) plays a key role in a diverse range of physiological and pathophysiological conditions within the cardiovascular, immune, reproductive and nervous systems. Since NO is a small, diffusible, highly reactive free radical with a short half-life, and is present in low concentrations, real-time detection of NO is extremely difficult. This meeting will examine methods used to detect and visualise NO-producing cells. Furthermore, direct and indirect techniques used to measure NO will be examined, including among others, the measurement of NOS enzymatic activity, electron paramagnetic resonance (EPR) and NO-sensitive electrodes. Finally, tools that facilitate NO research, such as NOS inhibitors will be examined". Meeting's Chair: Dr Nicholas Warrick - University of Oxford
"Nitric oxide (NO), generated by the enzyme nitric oxide synthase (NOS) plays a key role in a diverse range of physiological and pathophysiological conditions within the cardiovascular, immune, reproductive and nervous systems. Since NO is a small, diffusible, highly reactive free radical with a short half-life, and is present in low concentrations, real-time detection of NO is extremely difficult. This meeting will examine methods used to detect and visualise NO-producing cells. Furthermore, direct and indirect techniques used to measure NO will be examined, including among others, the measurement of NOS enzymatic activity, electron paramagnetic resonance (EPR) and NO-sensitive electrodes. Finally, tools that facilitate NO research, such as NOS inhibitors will be examined". Meeting's Chair: Dr Nicholas Warrick - University of Oxford
Contents
Introduction
- NITRIC OXIDE
- NITRIC OXIDE SYNTHASE
- ACTIONS OF NITRIC OXIDE
- MEETING OUTLINE
- REFERENCESÂ
ORAL PRESENTATIONS
- Quantification of Blood and Tissue NO Metabolites by Gas Phase Chemiluminescence: a Guide to NO Man's Land
- Vascular Nitric Oxide Metabolism
- Methods for Metabolite Measurement
- Principle of Chemiluminescence
- Radiochemical HPLC measurement of nitric oxide synthesis (NOS) activity in vascular tissue
- EPR-based measurement of reactive nitrogen intermediates in human inflammatory diseases
- Nitric oxide sensors and their biomedical applications
- Understanding NO synthase inhibition; potency, selectivity and implications for their pharmacology
- Endogenously occurring inhibitors of nitric oxide synthase
- Methylated arginines as NOS inhibitors
- Measuring ADMA
- Conditions in which ADMA is elevated
- Arginine methylation
- Regulation of ADMA
- Could ADMA be causative in cardiovascular pathologies?
- Evaluating endothelial function in humans: From bench to bedside
- Nitric oxide synthase inhibition and renal injury
- Quantification of enzyme independent stores of nitric oxide in human skin
POSTER Â PRESENTATIONS
- NO quantification in abnormal and manipulated red blood cells
- References
- Application of NO detection using Fe(DETC) spin trap and ESR spectroscopy in pharmacological research
- Halogenated volatile anestherics (HVA)
- Flavonoids. Baicalein and luteolin
- Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes
- Nitrite regulation of energy expenditure in man
- Nitric oxide inhibits cellular lipid and protein synthesis without energy depletion: a process of chronic diseases due to nitrosothiols
- NOx concentrations in human brain extracellular fluid and their relationship with energy metabolism: a pilot microdialysis study in acute brain injury
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