Handbook of Drug Screening, Second Edition (Drugs and the Pharmaceutical Sciences)

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.

With extensively updated content and 21 new chapters, this text examines:

• quality and efficiency of drug target validation and potential drug compound selection


• reducing assay costs and improvement in assay technology


• data quality improvement


• trends in drug discovery


• how drug screening can minimize adverse drug effects


• recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry