Pharmacology - Anti-Cancer Drug - A High Yield Review for Pharmacy Students (1)

Anti-Cancer Drugs
Cell-Cycle Specific – DNA Polymerase Inhibitors (S-phase) – include MTX, 5-FU, ara-C, 6-MP, Etoposide, Bleomycin, Taxol
Decrease PyrimidineSynthesis (Antimetabolites)
• Methotrexate (MTX) –PO inhibitor of DHF reductase (like trimethoprim, pyrimethamine, proguanil), resulting in decreased dTMP … Used for Leukemias/lymphomas, Choriocarcinoma, sarcoma, abortion/ectopic pregnancy, RA, and Psoriasis.