Understanding Acute Myelogenous Leukemia (AML) (Cancer.im Book 1)
Book Details
Author(s)Kevin Buckman MD, Dr Barkat Charania
Publisherwww.cancer.im
ISBN / ASINB00GYYGILG
ISBN-13978B00GYYGIL2
MarketplaceIndia 🇮🇳
Description
Acute myelogenous leukemia (AML), also known as acute myeloid leukemia, is a malignancy of the bone marrow in which leukocyte precursors (the immature bone marrow cells that are destined to give rise to the white blood cells) become arrested at a primitive stage of development. Current thinking is that it is actually a two-stage process during which an initial mutation occurs in one specific receptor site, and this manifests itself by providing a proliferative advantage to one particular cell line.
Acute leukemias have the characteristics of, and are derived from, primitive blood-making cells. (The cells that typify chronic leukemias, on the other hand, resemble more mature cells.)
There are two basic categories of adult acute leukemias, lymphoblastic and myelogenous. The difference between lymphoblastic and myelogenous leukemias is basically a function of the stage at which the cell line’s development becomes arrested. Myelogenous leukemias are characterized by an excess of myeloblasts (immature myelocytes), whereas the much commoner lymphoblastic leukemias are characterized by an excess of lymphoblasts (immature lymphocytes).
Acute leukemias of both types are therefore defined by the presence of these early "blast" forms of white cells that become arrested at a primitive stage of cellular development and do not go on to become mature. Leukemic cells accumulate in vast numbers in the bone marrow cavity, ultimately replacing the bulk of the normal cells. The presence of all these immature cells interferes with the normal functioning of the bone marrow and the blood. The result is that normal cells are diminished in number to the point where they may not even be functionally evident at all. This leads to such symptoms as bruising, bleeding, and even infections.
AML (Acute Myelogenous Leukemia) is an aggressive tumor of the blood and bone marrow. AML is the most common type of leukemia. In such cases the leucocyte precursors gets detained at the initial stage of development. The immature bone marrow cells in the human body are ordained to increase white blood cells, but do not happen in this medical condition. This is actually a two stage process, in the first stage initial transformation occurs in one particular receptor site, it is clear that it provides a proliferative advantage to one specific cell line.
Primitive blood making cells characterize acute leukemias and at the same time these cells resembles more mature cells. Adult acute leukemias is divided in to two basic categories, they are myelogenous and lymphoblastic. The main difference between these two types of leukemias is that the stage at which the development of cell lines are arrested. Excess number of immature myelocytes is the main reason for myelogenous leukemias where as lymphoblastic leukemias are typifies by a surplus of immature lymphocytes.
Lymphoblastic and myelogenous, both types of acute leukemias happen because of the early blast of white cells which automatically gets arrested at a primitive stage of cellular development. The main issue at this stage is that these cells do not become mature. Bulk number of normal cells gets replaced by the accumulation of leukemia cells in the bone marrow cavity. The normal functioning of the bone marrow and blood gets affected to a large extent because of the interference of immature cells. In this process the normal cells gets diminished to a greater extent that they may not even be functionally evident. Symptoms such as bleeding, infection and bruising arise at this stage.
Acute leukemias have the characteristics of, and are derived from, primitive blood-making cells. (The cells that typify chronic leukemias, on the other hand, resemble more mature cells.)
There are two basic categories of adult acute leukemias, lymphoblastic and myelogenous. The difference between lymphoblastic and myelogenous leukemias is basically a function of the stage at which the cell line’s development becomes arrested. Myelogenous leukemias are characterized by an excess of myeloblasts (immature myelocytes), whereas the much commoner lymphoblastic leukemias are characterized by an excess of lymphoblasts (immature lymphocytes).
Acute leukemias of both types are therefore defined by the presence of these early "blast" forms of white cells that become arrested at a primitive stage of cellular development and do not go on to become mature. Leukemic cells accumulate in vast numbers in the bone marrow cavity, ultimately replacing the bulk of the normal cells. The presence of all these immature cells interferes with the normal functioning of the bone marrow and the blood. The result is that normal cells are diminished in number to the point where they may not even be functionally evident at all. This leads to such symptoms as bruising, bleeding, and even infections.
AML (Acute Myelogenous Leukemia) is an aggressive tumor of the blood and bone marrow. AML is the most common type of leukemia. In such cases the leucocyte precursors gets detained at the initial stage of development. The immature bone marrow cells in the human body are ordained to increase white blood cells, but do not happen in this medical condition. This is actually a two stage process, in the first stage initial transformation occurs in one particular receptor site, it is clear that it provides a proliferative advantage to one specific cell line.
Primitive blood making cells characterize acute leukemias and at the same time these cells resembles more mature cells. Adult acute leukemias is divided in to two basic categories, they are myelogenous and lymphoblastic. The main difference between these two types of leukemias is that the stage at which the development of cell lines are arrested. Excess number of immature myelocytes is the main reason for myelogenous leukemias where as lymphoblastic leukemias are typifies by a surplus of immature lymphocytes.
Lymphoblastic and myelogenous, both types of acute leukemias happen because of the early blast of white cells which automatically gets arrested at a primitive stage of cellular development. The main issue at this stage is that these cells do not become mature. Bulk number of normal cells gets replaced by the accumulation of leukemia cells in the bone marrow cavity. The normal functioning of the bone marrow and blood gets affected to a large extent because of the interference of immature cells. In this process the normal cells gets diminished to a greater extent that they may not even be functionally evident. Symptoms such as bleeding, infection and bruising arise at this stage.
